Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models
نویسندگان
چکیده
منابع مشابه
Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models
Cognitive impairment in Down syndrome (DS) has been linked to increased synaptic inhibition. The underlying mechanisms remain unknown, but memory deficits are rescued in DS mouse models by drugs targeting GABA receptors. Similarly, administration of epigallocatechin gallate (EGCG)-containing extracts rescues cognitive phenotypes in Ts65Dn mice, potentially through GABA pathway. Some development...
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Down syndrome (DS) is caused by the overexpression of genes on triplicated regions of human chromosome 21 (Hsa21). While the resulting physiological and behavioral phenotypes vary in their penetrance and severity, all individuals with DS have variable but significant levels of cognitive disability. At the core of cognitive processes is the phenomenon of synaptic plasticity, a functional change ...
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ژورنال
عنوان ژورنال: Frontiers in Behavioral Neuroscience
سال: 2015
ISSN: 1662-5153
DOI: 10.3389/fnbeh.2015.00267